This proposal for renewal of the Cancer Center Support Grant (Comprehensive) for the Fred Hutchinson Cancer Research Center of Seattle is to develop support for professional personnel, administration, planning and evaluation, shared resources and services, developmental funds, equipment supplies, clinical oncology units, and community outreach and cancer education programs. Basic science programs involving Tumor Immunology, Biochemical Oncology, Carcinogenesis, Related Organic Chemistry, Medical Oncology with various subdivisions, Viral Oncology, Projected Oncologic Pharmacology, Pathology and Electronmicroscopy are presently underway. Other programs in the Extramural area will involve Biostatistics/Epidemiology, Library Services and Information, Rehabilitation Medicine, Social Epidemiology of Cancer Care, the Extramural Council of the FHCRC and the Pacific Northwest Cooperative Cancer Study Group. The Center itself functions not only as an architectural but as a programmatic focus for other aspects of cancer research involving Therapeutic Radiology, Pediatric Oncology, Cancer Detection Programs in conjunction with the American Cancer Society, University of Washington, regional and local hospitals and practicing physicians has been obtained. It is anticipated that the Fred Hutchinson Cancer Research Center will function as a truly comprehensive cancer center for the Pacific Northwest region.